A compact device incorporating CRISPR technology revolutionizes on-site detection of pathogenic viruses with a fast-speed (within 20 min) and high-sensitive nucleic acid detection method in one tube. Its small size and portability make it ideal for field applications, providing immediate and accurate virus detection in various settings. This breakthrough in on-site virus detection enhances rapid response capabilities, allowing for timely interventions and effective containment of viral outbreaks.